Nobel Prize for Oxygen Sensing and Hypoxia: the Environmental Relevance of PhenomenaTiistai 8.10.2019 klo 9.37 - Mikko Nikinmaa One of the most conspicuous changes that occur in the aquatic environment is the increasing occurrence of hypoxic areas. The Nobel Prize in Physiology and Medicine is this year given to three scientists, Kaelin, Ratcliffe and Semenza, who have studied and discovered the mechanism of how oxygen deficiency controls gene expression in man. Compared to air-breathers, fish and other aquatic animals must get by with 1/30th of the oxygen concentration. They are further faced with marked variations in oxygen level both daily and seasonally (or unknown periods of time). Further, since fish are poikilothermic, temperature changes affect their oxygen requirements conspicuously. The oxygen sensing and transport system of fish must therefore be more v Given that oxygen is a limiting factor in aquatic environment, it is no surprise that HIF system in fish has evolved differently in different fish groups depending on their oxygen requirements. In continuation, the possibilities of fish to adapt to climate change and environmental pollution are markedly affected by what their HIF system is. Thus, the Nobel Prize winning studies have a significant environmental angle. This has been reviewed to some extent in Nikinmaa, M. and Rees, B.B. (2005) Oxygen-dependent gene expression in fishes. Am. J. Physiol. - Regul. Integr. Comp. Physiol. 288, 1079-1090 and in Prokkola, JM and Nikinmaa M (2018) Circadian rhythms and environmental disturbances - underexplored interactions. J. Exp. Biol. 221, jeb179267. The evolution of HIF system in animals was explored in Rytkönen KT et al (2011) Molecular Evolution of the Metazoan PHD–HIF Oxygen-Sensing System. Mol. Biol. Evol. 28: 1913-1926. |
Kommentoi kirjoitusta. Avainsanat: climate change, temperature, hypoxia, evolution, environmental pollution |